CD8A and dengue disease: The kinetics and phenotype of CD8+ T cell induction and maintenance in humans has also been examined following vaccination with Takeda's live-attenuated tetravalent dengue vaccine (TDV) consisting of an attenuated DENV2 strain (TDV-2), and three chimeric viruses encoding the pre-membrane (prM) and E proteins of DENV1, 2, or 4 on the TDV-2 backbone.