However, the Trib1-depleted mice exposed to I/R presented increased collagenous fiber levels and extensive tubulointerstitial damage from day 3 to day 28 when compared with moderate IRI mice and Trib1-knockdown alone mice, implying that Trib1 inhibition impeded the process of repairing histological damage and fibrosis in I/R-induced AKI (Figure 3C). This evidence concerns the gene TRIB1 and acute kidney injury.