CD80 and preeclampsia: Villitis of unknown etiology (VUE), chorioamnionitis-induced spontaneous preterm birth, severe preeclampsia, and HELLP syndrome are related to a shift in the macrophage phenotype from M1 to M2, and this shift is accompanied by a change in the phenotypic markers from CD80/CD86 to CD163/CD206 (38, 39).