RA patients also expressed significantly more IgG+veCD27−ve B cells that lacked expression of CD24, CD38, and CD21, which are akin to double negative 2 (DN2) (9) B cells known to be associated with more severe, active systemic lupus erythematosus (SLE) (10, 11). The gene discussed is CD38; the disease is systemic lupus erythematosus.