NFKB1 and myeloid sarcoma: To assess the impact of NF-κB on normal oligodendrocyte maturation, demyelination, and remyelination in an MS background, Raasch et al. depleted IKKβ in CNS cells (IKKβCNS-KO) and oligodendrocytes alone (IKKβOligo−KO) (47).