Moreover, the team identified that the presence of MS risk variant rs228614 proximal to NF-κB1 resulted in increased degradation of IκBα and NF-κB p65 phosphorylation in both TNF-α-stimulated or PMA (phorbol 12-myristate 13-acetate)–stimulated CD4+ T cells (34). The gene discussed is RELA; the disease is myeloid sarcoma.