For this, we performed a multinomial logistic analysis relating to the percentage of Hes-1-positive cells in these structures with gene findings (Jagged-1, Notch-1) and histopathological findings (trophic changes, inflammatory changes, and involvement of dermal nerves) in which a difference was found between leprosy and non-leprosy samples (Table 3, Table S3). This evidence concerns the gene HES1 and leprosy.