To address this issue, we separated by stage the 129 CRC pairs (79 CRC pairs as well as 50 CRC pairs/TCGA_38 cohort) into 57 low stage tumors (TNM stage I/II) and 82 high stage tumors (TNM stage III/IV) and found that there was no significant difference (p = 0.81) in the expression of IFI30, GBP1, GBP4, PD1, PDL1, CTLA4, Tim3, LAG3, IFNγ, and IDO1 between low and high stage CRCs (Figure S6). The gene discussed is GBP4; the disease is colorectal carcinoma.