Eleven co-stimulatory genes (C10orf54 [B7-H5], BTLA4, CD86, CD80, ICOS, CD28, CD27, CD40, TNFRSF9 [4-1BB], TNFRSF18 [GITR], TNFRSF4 [OX40]) (30, 31) were expressed at higher (1.5-fold) levels in IFNγ positive vs. IFNγ negative CRC, but this did not reach statistical significance (p = 0.30) (Figure S3B). The gene discussed is ICOS; the disease is colorectal carcinoma.