In IFNγ positive CRC, the following was observed: (i) IFNγ, CD8A, CD8B, and CD4 co-expression with all six ICPs genes within one network (190 genes); (ii) IFNγ and three ICPs (LAG3, Tim3, and IDO1) were defined as potential hub genes due to their substantial number of co-expressed genes (n > 45); and (iii) co-expression of IFNγ and six ICPs with 129 immune cell related genes (pale blue dots in Figure 2A) and 54 signaling genes (red dots in Figure 2A; Table S8). Here, IDO1 is linked to colorectal carcinoma.