IFNG and colorectal carcinoma: To further define the dosage impact of IFNγ on the expression of six ICPs and three ICPRGs, we generated six IFNγ expression level gradients 1 IFNγ: FPKM > 5 (4 CRCs); (1) IFNγ: FPKM = 4.9–2 (20 CRCs); (2) IFNγ: FPKM = 1.99–1(44 CRCs); (3) IFNγ: FPKM = 0.99–0.5 (73 CRCs); (4) IFNγ: FPKM = 0.49–0.01 (467 CRC); and (5) IFNγ: FPKM < 0.009 (107 CRCs) in 716 CRCs (Indivumed [79 CRCs] and TCGA [637 CRCs]) (Figure 5A) and examined the impact of the levels on expression of the ICPs and ICPRGs examined in our more limited cohort.