IFNG and neoplasm: Although IFNγ secreted by immune cells promotes growth arrest of tumors by augmenting MHC class I expression, contributing to the recruitment of effector cells, mediating Treg fragility and coordinating innate and adaptive antitumor responses (33, 34), IFNγ signaling can also compromise antitumor immunity by blocking these activities through the induction of immune checkpoint inhibitory molecules on T and tumor cells (35).