IGHG3 and Zika virus infectious disease: Limited data from a long-term cohort study in Brazil before and after the 2015 ZIKV outbreak have found that the pre-existing DENV NS1 specific IgG3 antibody within 4–6 months of infection was positively associated with the risk of subsequent ZIKV infection, but high titer of total IgG to DENV was associated with protection against the acquisition of ZIKV infection (Rodriguez-Barraquer et al., 2019).