Alleviating the inflammation state in obesity may restore insulin sensitivity as targeting inflammation in diet induced obesity in mice leads to a decrease in adipocyte area, macrophage infiltration, proinflammatory gene expression, along with JNK and NF-κB activation and increased insulin sensitivity via increased AKT phosphorylation (186, 187). The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.