Indeed, ZAG has emerged as a multifunctional adipokine that involved in the development of various obesity-related disorders, including insulin resistance (33, 35), T2DM (36, 37), hypertension (38, 39), NAFLD (40), polycystic ovary syndrome (PCOS) (41), and Cushing syndrome (42). Here, AZGP1 is linked to Hypertension.