Indeed, ZAG has emerged as a multifunctional adipokine that involved in the development of various obesity-related disorders, including insulin resistance (33, 35), T2DM (36, 37), hypertension (38, 39), NAFLD (40), polycystic ovary syndrome (PCOS) (41), and Cushing syndrome (42). Here, AZGP1 is linked to polycystic ovary syndrome.