DNMT3A and major depressive disorder: Following post hoc multiple comparisons correction in the interaction analyses of SNPs and daily life stress or pleasant experiences, respectively, in the discovery sample, only one SNP was validated as significant and directionally similar in the replication sample and furthermore in the sample of patients with a MDD lifetime history: The minor rs11683424 T allele in the gene coding for the DNA methyltransferase 3 alpha (DNMT3A) was associated with a reduced impact of daily life stress on negative affectivity.