TRPML1 could play an important role in restoring autophagy and lysosome function in ALS, given that Ca2+ release is crucial for lysosome function, that TRPML1 is implicated in lysosomal Ca2+ release, and that PI(3,5)P2 levels are impaired in ALS. The gene discussed is MCOLN1; the disease is amyotrophic lateral sclerosis.