APOB and Insulin resistance: By affecting insulin resistance and lipid metabolism related pathways (e.g., PI3K-Akt, AMPK); activating cholesterol secretio; increasing serum thyroid hormone levels, improving beta-oxidation (via modulation of TR beta 1 and CPT1A expression), metabolism and transport (through modulation of SREBP-1c, ACSL and ApoB100 expression) of fatty acid.