Molecular targets of FAS, ACC1, ChREBP alpha, and SREBP-1c were also found to be involved in the underlying mechanism of anti-hepatic steatosis and anti-obesity-related hepatic inflammation effect of Gambigyeongsinhwan in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells (Yoon et al., 2017). This evidence concerns the gene SREBF1 and fatty liver disease.