attenuated liver steatosis in HFD-fed animals via regulating lipogenic genes, predominantly relating with downregulation of SREBP-1c expression via AMPK activation (Li et al., 2013; Li W. et al., 2014; Lee Y. H. et al., 2016; Yang et al., 2016; Lee et al., 2018; Lim et al., 2018; Ho et al., 2019). Here, SREBF1 is linked to fatty liver disease.