Berberine reduced steatosis in MIHA and HepG2 cells by mechanism associating with up-regulation of miR-373, which decreased its mRNA level target gene AKT serine/threonine kinase 1 (AKT1), resulting in the suppression of AKT-mTOR-S6K signaling pathway in hepatocytes (Cao et al., 2018). This evidence concerns the gene AKT1 and steatosis.