Figure 2 shows the overview of lipogenesis in hepatocytes. Herbs and isolated natural compounds have been demonstrated by animal studies and in vitro studies to alleviate hepatic steatosis by ChREBP pathway and insulin-SREBP-1c pathway, as well as other factors, such as AMPK, PPARγ, SIRT1, inflammatory cytokines, immuno-modulation, and microRNAs. We summarized medicinal herbs and isolated natural compounds from recent literatures with the effects of reducing hepatic lipogenesis in Table 2 and discussed some representative studies in detail as following. This evidence concerns the gene INS and fatty liver disease.