It also promotes cell differentiation, induces the secretion of adiponectin (Hu et al., 2018), increases the expression of T2DM rat skeleton (Liu et al., 2011a) and glucose transporter 4 (GLUT4) mRNA in adipose tissue (Liu et al., 2011b), decreases the expression of resistin mRNA, downregulates adipose tissue resistance protein in T2DM rats (Liu et al., 2012c), and increases the expression of AMPK in liver tissue of T2DM rats (Wu et al., 2009). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.