GSK3B and schizophrenia: In this context, a lower expression/density and activity of Akt (Zhao et al., 2006) and GSK3β (Emamian et al., 2004) has been described in the PFC of subjects with schizophrenia, although there are contradictory reports (Ide et al., 2006; Amar et al., 2008; Kitagishi et al., 2012; McGuire et al., 2017).