AKT1 and schizophrenia: The downregulation of Akt/mTOR signaling proteins in postmortem PFC of SZs (Chadha and Meador-Woodruff, 2020), together with postmortem studies showing that spine density is reduced in the cortex of schizophrenia patients (Glantz and Lewis, 2000; Konopaske et al., 2014) further support our results.