CAFs secrete specific cytokines, proteins, or exosomal miRNA to activate certain anti-apoptosis related signaling pathways like PI3K/Akt, ANXA3/JNK, and IL-11/IL-11R/STAT3, and consequently offer tumor cells the ability of resistance (Tao et al., 2016; Zhou et al., 2016a; Zheng et al., 2017b; Qin et al., 2019; Wang et al., 2019b). The gene discussed is AKT1; the disease is neoplasm.