The GS-platinum complex catalyzed by glutathione-S-transferase can reach to about 60% of the intracellular platinum content after 12-h incubation in leukemia cells (Ishikawa and Ali-Osman, 1993), and the elevated expression of GSH and glutathione-S-transferase are often seen in the resistant-cells (Masters et al., 1996; Byun et al., 2005). Here, HPGDS is linked to leukemia.