Deletion of the yeast CTR1 gene reduces the intracellular accumulation of cisplatin and leads to cisplatin-resistance (Ishida et al., 2002), while forced overexpression of hCTR1 sensitizes small cell lung cancer cells to cisplatin, carboplatin, and oxaliplatin (Song et al., 2004). Here, SLC31A1 is linked to small cell lung carcinoma.