SLC31A1 and ovarian carcinoma: It can be down-regulated by intracellular copper (Howell et al., 2010) or cisplatin/oxaliplatin treatment which triggers a rapid loss of hCTR1 via macropinocytosis and proteasomal degradation in ovarian carcinoma cells (Holzer and Howell, 2006) and hepatocellular carcinoma cells (Li et al., 2016b).