Many factors contribute to these unwanted phenomenons, such as pro-survival signal pathways (Sun et al., 2016; Bao et al., 2017) [i.e., MAPK/ERK (Kong et al., 2015), PI3K/AKT pathway, NF-κB (Miow et al., 2015)], and tumor microenvironment (TME) and epigenetic regulation (Benard et al., 2014; Ramadoss et al., 2017). Here, AKT1 is linked to neoplasm.