Moreover, the BDNF-activated PI3K-AKT-mTOR signaling pathway is reported to be essential in female reproductive diseases such as polycystic and premature ovarian failure, which may be induced by chronic unpredictable mild stress (Divyashree and Yajurvedi, 2016; Sun et al., 2017; Fu et al., 2018). Here, MTOR is linked to primary ovarian failure.