Tan I was explored that could cause the death of tumor multidrug resistance cells by inducing PARP, caspase-3, caspase-8, and caspase-9 cleavage and decreasing mitochondria membrane potential without influence on drug transporter proteins P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP1). Here, CASP3 is linked to neoplasm.