MTOR and leukemia: In another study, Tan IIA induced autophagic cell death viaactivation of AMPK and ERK and inhibition of mTOR and rapamycin(mTOR), ribosomal protein S6 kinase (p70 S6K) in KBM-5 leukemia cells(Yun et al., 2013; Han et al., 2018).