On this line, NF-κB dysregulation has been found to participate in brain neurodegenerative mechanisms occurring in PD (Hunot et al., 1997), Alzheimer’s disease (AD) (Kaltschmidt et al., 1997; Chen et al., 2012; Jones and Kounatidis, 2017), as well as in post-traumatic or post-ischemic brain injury (Bethea et al., 1998; Schneider et al., 1999). The gene discussed is NFKB1; the disease is brain injury.