In this regard, studies showing that post-stroke induction of α-syn mediates ischemic brain damage (Ishimaru et al., 1998; Hu et al., 2006; Yoon et al., 2006; Unal-Cevik et al., 2011; Surgucheva et al., 2014; Kim T. et al., 2016) and that the levels of oligomeric form of α-syn of red blood cells in ischemic stroke and PD patients are both significantly higher than in controls (Zhao et al., 2016), seem to shed light on a possible link between NF-κB dysregulation and α-syn accumulation that deserves to be addressed by ad hoc studies. This evidence concerns the gene NFKB1 and Parkinson disease.