NFKB1 and neurodegenerative disease: NF-κB factors play a crucial role in the regulation of inflammation and apoptosis, are involved in the brain programming of systemic aging, as well as in the pathogenesis of several neurodegenerative diseases (Sarnico et al., 2009a; Mincheva-Tasheva and Soler, 2013; Lanzillotta et al., 2015).