In this regard, a number of evidences suggest that soluble oligomeric forms of Aβ (sAβos), identified in AD patients (Gong et al., 2003; Fukumoto et al., 2010) and AD animal models (Mucke et al., 2000; Price et al., 2014), precede the fibrillar amyloid deposition and tau pathology and have been implicated in the synaptopathy observed before the neurodegeneration appearance (Selkoe, 2008; Sheng et al., 2012). The gene discussed is MAPT; the disease is Alzheimer disease.