PANX1 and Alzheimer disease: Moreover, Panx1 overactivity has also been involved in the Aβ-triggered degranulation of mast cells (Harcha et al., 2015) and in the aberrant gliotransmission that promotes early inflammatory processes in AD mouse models (Yi et al., 2016, 2017), suggesting that neuro-inflammation could directly increase Panx1 expression and activation in the brains of Tg mice.