PANX1 and Alzheimer disease: Interestingly, Panx1 exhibited a punctate staining pattern around amyloid plaques, in the pyramidal cell layer, neuropil, and reactive astrocytes (Supplementary Figure S1D), in agreement with previous observations that Panx1 is expressed in reactive astrocytes that are in direct contact with amyloid plaques in this AD model (Yi et al., 2016).