PANX1 and Alzheimer disease: In this regard, the observations that the Panx1 blocker PBN (Silverman et al., 2008) is capable of reversing LTP and LTD impairments in Tg hippocampal slices (Figures 3A–D) support the idea that an exacerbated Panx1 activity could be an important player in the early synaptic dysfunction that affects AD brains.