Since p38MAPK signaling modulates inflammatory cytokine production (Corrêa and Eales, 2012; Colié et al., 2017) and Aβ accumulation (Colié et al., 2017), two factors that increase Panx1 activation and plasma membrane expression (Orellana et al., 2011b; Negoro et al., 2013), it is feasible that a “positive loop” between Panx1 and p38MAPK exacerbates their activities, amplifying Aβ-induced neurotoxicity in AD (Figure 6). The gene discussed is PANX1; the disease is Alzheimer disease.