BACE-1, sAPPβ: AD↑, FTD n.s.  GDNF: AD/MCI↓, FTD n.s.  BACE-1, γ-secretase, Aβ42, sAPPα, sAPPβ, GDNF, pT181-tau, pS396-tau: ADE of all groups↑ compared to NDE. The gene discussed is BACE1; the disease is Alzheimer disease.