We believe that this study, and others that reflect on the role of IAPP in AD in an unbiased manner (Mietlicki-Baase, 2018) complemented by further experiments, will certainly pave the road to future IAPP-centered drug development strategies against AD, as we considering it as the result of a “diabetes brain phenotype.” Such a view will certainly yield major therapeutic advances. This evidence concerns the gene IAPP and diabetes mellitus.