In heterozygous hIAPP+ mice with β cell–specific Atg7 deficiency (hIAPP+Atg7Δβcell mice), the accumulation of toxic oligomers, the loss of β-cells, and diabetes development is linked to autophagy disruption, and this is suggestive of a role for autophagy in IAPP toxicity (Kim et al., 2014). This evidence concerns the gene IAPP and diabetes mellitus.