Moreover, Nix has been shown to be involved in the pathophysiological processes of various central nervous system (CNS) diseases, including cerebral ischemia-reperfusion (I/R) injury, intracranial hemorrhage, spinal cord injury and neurodegenerative diseases; however, the specific mechanisms of Nix in the pathophysiology of these CNS diseases remain unclear (Rui et al., 2013; Yu et al., 2013; Park et al., 2017; Yuan et al., 2017). This evidence concerns the gene BNIP3L and brain ischemia.