The “magenta” module contained genes such as ABI3, CD33, MS4A46, MS4A6S, TREM2, and TYROBP, which have been previously linked to AD through protein-coding mutations (Naj et al., 2011; Sims et al., 2017) and are all critical to microglial activation and response (Satoh et al., 2017). This evidence concerns the gene TREM2 and Alzheimer disease.