MAPT and tauopathy: Late-onset Alzheimer’s disease (LOAD) is a complex condition involving tau protein aggregates or tauopathy, amyloid and lipid processing, aging, immune system response, metabolism, lysosomal processing, and cerebrovascular health (Rogers et al., 1988; Braak et al., 2011; Jevtic et al., 2017; Wang et al., 2017).