On the other hand, the use of intensive insulin therapy with tight glycemic control could have overall deleterious effects for the patients, especially for those with severe TBI, possibly due to hypoglycemia (Investigators et al., 2009; Blackburn et al., 2010; Nice-Sugar Study Investigators for the Australian, New Zealand Intensive Care Society Clinical Trials Group, and the Canadian Critical Care Trials Group et al., 2015; van der Jagt, 2016). This evidence concerns the gene INS and Hypoglycemia.