Univariate analysis revealed that histological grade (P = 0.006; HR, 2.52; 95% confidence interval [CI]: 1.3–4.86), nuclear grade (P = 0.005, HR, 2.57; 95% CI: 1.33–4.94), and ACTN4 FISH (P = 0.002, HR, 3.62; 95% CI: 1.59–8.27) were significantly correlated with recurrence of breast cancer. This evidence concerns the gene ACTN4 and breast carcinoma.