Univariate Cox regression analysis showed that ACTN4 CNI was the sole factor significantly associated with high risks of recurrence (P = 0.04; HR, 2.73; 95% CI 1.03–7.24) and breast cancer death (P = 0.016; HR, 4.01; 95% CI: 1.29–12.49) (Supplementary Tables S2 and S3). This evidence concerns the gene ACTN4 and breast carcinoma.