We further analysed the change in the distribution of M-MDSCs (CD11b+Ly-6C+ cells) and PMN-MDSCs (CD11b+Ly-6G+ cells), and found significantly fewer M-MDSCs in these tissues in HSD-fed mice than in NSD-fed mice of both tumour models (Fig. 3d, Supplementary Fig. 7a–c), while little difference was observed in the percentage of PMN-MDSCs (Fig. 3e, Supplementary Fig. 7a–c). This evidence concerns the gene ITGAM and neoplasm.