NFAT5 and neoplasm: In the tumour-bearing mice treated with HSD, NFAT5 silencing in M-MDSCs and macrophages (though adoptively transferred NFAT5-deficient macrophages in vivo could weaken antitumour capacity26) could partly restore tumour growth, because PMN-MDSC’s function switch affected by HSD could also display antitumour ability (Supplementary Fig. 17a–c).