TARDBP and amyotrophic lateral sclerosis: To evaluate whether the expression of the ALS- and FTD-U-linked C-terminal fragment of TDP-43 affects accumulation of astroglial LDs, we stained non-transfected cells and cells expressing RFP-TDP-43wt and RFP-TDP-43208–414 with a fluorescent LD marker BODIPY493/503 (Fig. 2).