In the case of EAE, LDV infection prior to MOG/CFA immunization blunted the production of IL-12 and IL-23 by cDC in the dLN, resulting in the absence of IFN-γ, IL-17, and GM-CSF production by MOG-specific CD4+ T cells, both in the periphery and in the CNS. Here, CD4 is linked to infection.