To further analyze the role of these factors in IAV infection, we measured the kinetics of virus production upon siRNA knockdown of each DDB1, DCAF11, and DCAF12L1 factor using the fully lab-adapted strain H1N1WSN, and seasonal H1N1pdm09 and H3N2 strains, which were recently adapted to in vitro infection (18). The gene discussed is DDB1; the disease is infection.