AGER and Cognitive impairment: Our results also imply that AT2 receptor activation in the cerebrovasculature could play a preventive role in this worsening of cognitive function through inhibition of oxidative stress, inflammation, impaired RAGE-mediated Aβ clearance system, and neuronal degeneration, thus supporting the notion that targeting AT2 receptor activation might be useful for a new generation of therapeutic or preventive strategies targeting Aβ peptide for cognitive impairment or dementia, due to its multiple protective actions both in the vascular system and in the CNS.