VEGFA and Cognitive impairment: Our results indicated that cerebrovascular damage mechanisms might contribute to a faster and exacerbated development of neuropathology and cognitive deficit in our mouse model, since BCCAO alone significantly downregulated hippocampal expressions of cerebrovascular function markers, collagen IV, and vascular endothelial growth factor A (VEGF-A) in WT mice, whereas Aβ injection alone had no effects on them.