AGTR2 and Mental deterioration: In the present study, mice with AT2 receptor overexpression in VSMC, smAT2 mice exhibited similar cognitive function to WT mice, and Aβ injection with/without BCCAO did not result in a significant decline in cognitive performance with no cerebrovascular alterations in smAT2 mice (Supplemental Figure S3), suggesting that AT2 receptor activation might ameliorate cerebrovascular damage and further cognitive decline in our mouse model.