Although additional confirmation is required, we propose here that transient cerebral ischemia may cause cerebrovascular damage and then enhance excessive Aβ in the brain via disruption of RAGE-mediated Aβ clearance system through oxidative stress and inflammation, and Aβ, in turn, may promote the development of cerebral ischemia through amplified oxidative stress and inflammation, thereby contributing ultimately to the full cognitive decline of ischemia with Alzheimer type in a vicious cycle. Here, AGER is linked to brain ischemia.