AGER and Cerebral ischemia: Therefore, we demonstrated here that in response to cerebral ischemia combined with Aβ1-40 infusion, the level of soluble Aβ1-40 oligomers is elevated in the brain accompanied by enhanced RAGE expression associating with impairment of Aβ1-40 clearance system and mainly contributes to the amplified oxidative stress, glia inflammation, neuronal damage, and final deteriorated cognitive function.