Our results also imply that AT2 receptor activation in the cerebrovasculature could play a preventive role in this worsening of cognitive function through inhibition of oxidative stress, inflammation, impaired RAGE-mediated Aβ clearance system, and neuronal degeneration, thus supporting the notion that targeting AT2 receptor activation might be useful for a new generation of therapeutic or preventive strategies targeting Aβ peptide for cognitive impairment or dementia, due to its multiple protective actions both in the vascular system and in the CNS. Here, AGTR2 is linked to Cognitive impairment.