Furthermore, the CAF-derived cytokines CCL5 (chemokine ligand 5), IL6, and CXCL10 (C-X-C motif chemokine 10 regulate the metabolism of cancer cells by increasing phosphorylation of phosphoglucomutase 1 and glycogen mobilization, nicotinamide adenine dinucleotide phosphate (NADPH) synthesis and the tricarboxylic acid (TCA) cycle, which facilitates the proliferation and metastasis of ovarian cancer cells in vivo [72]. This evidence concerns the gene IL6 and cancer.