For one, TAM strengthens angiogenesis by production of VEGF-A, TNFα, urokinase plasminogen activator (uPA), FGF, adrenomedullin (ADM), and semaphorin 4D (Sema4D) thymidine phosphorylase (TP), lymphangigensis (secretion of VEGF-A, VEGF-C, VEGF-D, CXCL8, MMP2, MMP9) fueling cancer invasion and metastasis [96, 98, 99]. This evidence concerns the gene SEMA4D and cancer.