In this line, a study in human colorectal cancer (CRC) specimens and in vitro co-culture, revealed that TAMs induce EMT program to enhance CRC invasion, migration, and CTC-mediated metastasis by producing IL6 to activate JAK2/STAT3 axis and inhibit the suppressive role of miR-506-3p on FoxQ1 expression. The gene discussed is STAT3; the disease is colorectal carcinoma.