RBFOX3 and Alzheimer disease: However, when we analyzed AD mice (APP/PS1 and APP/PS1-EMP) separately, we observed an overall improvement of different pathological features, including cortical NeuN/DAPI ratio, microglia burden in the proximity of SP, or SP density in the cortex and hippocampus, accompanied by better performance in the MWM test, supporting a role for EMP specifically associated to AD pathology in APP/PS1 mice.