Importantly, T-cell migration into IL6-producing tissues is prevented by the expression of selectin-L (SELL/CD62L) [57], which is directly downregulated by IL6 [58], while favoured by upregulation of CXCR4/CXCR5/CCR3, which we previously showed to be increased on CD62-naïve CD4+ T-cells in RA [59]. This evidence concerns the gene IL6 and rheumatoid arthritis.