The neuroinflammatory response-related genes were induced peaking at day 1 to 14 post-stroke, including microglial cell activation (Tlr1–8, Tnf, Tyrobp), positive regulation of microglial cell activation (Mmp8), negative regulation (Cst7) and regulation (cd200r2, cd200r3, cd200r4) of neuroinflammatory response, and astrocyte activation (C1qa, C5ar1, Fpr2, Grn, Il1b, and Trem2) (Supplementary Fig. S7). This evidence concerns the gene MMP8 and stroke disorder.