Using the genes from the top three pathways, including 23 STAT3, 3 HKII and 19 p70S6K pathway genes, we then screened these 45 genes for their potential to predict patient outcomes using TCGA cancer datasets in Head-Neck Squamous Cell Carcinoma (HNSC) patients (Fig. 7a-g). This evidence concerns the gene HK2 and head and neck squamous cell carcinoma.