PRKN and Parkinson disease: Approximately 10% of PD cases are inherited as genetic mutations of SNCA (α-synuclein), PARK2 (Parkin), PINK1 (PTEN-induced kinase 1), PARK7 (protein deglycase DJ-1), LRRK2 (leucine-rich repeat kinase) or ATP13A2 (ATPase type 13A).