MAPT and Alzheimer disease: Some well-known hallmarks of neurodegenerative diseases include mutant hungtingtin (mHTT) aggregates in Huntington’s disease (HD) [7], α-synuclein-associated Lewy bodies in Parkinson’s disease (PD) [8], Amyloid-β aggregation and hyperphosphorylated Tau in Alzheimer’s disease (AD) [9], and TDP43 proteinopathies in frontotemporal lobe dementia (FTLD) [10] and amyotrophic lateral sclerosis (ALS) [11].