CASQ2 and catecholaminergic polymorphic ventricular tachycardia: The overall deleterious effects on Ca handling and arrhythmogenesis observed in the present study with conditional overexpression of SERCA in CPVT (i.e. CASQ2-KO) mice are in agreement with those obtained utilizing constitutive SERCA1a overexpression in the same CASQ2-KO background [15].