Some systemic inflammatory cytokines such as nuclear factor kappa light chain enhancer of activated B cells (NF-κB); C-reactive protein (CRP); tumor necrosis factor-α (TNF-α); Interleukin (IL)-6, IL-8, IL-1α, and IL-1β; and Interferon-γ (IFN-γ) are related to pediatric OSA. The gene discussed is TNF; the disease is obstructive sleep apnea syndrome.