McDermott and colleagues explored three gene expression signatures: angiogenesis, T-effector/IFN-γ response, and myeloid inflammatory genes in ccRCC (n = 263) from IMmotion 150 trial: a phase 2 trial before IMmotion 151 of atezolizumab (anti-PD-L1) alone or combined with bevacizumab (anti-VEGF) versus sunitinib [76]. The gene discussed is CD274; the disease is nonpapillary renal cell carcinoma.