To this end, we used glioblastoma cells proficient (M059K) and deficient (M059J) in DNA-PKcs, as well as pancreatic cancer cells without (BxPC3) and with a naturally occurring 6174delT mutation in one BRCA2-allele accompanied by loss of the wild-type allele (Capan-1). The gene discussed is PRKDC; the disease is familial pancreatic carcinoma.