To corroborate our findings on the impact of DNA repair-deficiencies on radiation response in cancer cell models, we used the DNA-PKcs-deficient M059J and DNA-PKcs-proficient M059K glioblastoma cell lines as well as the pancreatic cell lines BxPC3 with intact BRCA2 and Capan-1 with reported deficiency in BRCA2 expression. Here, PRKDC is linked to cancer.