NCT03225664 is a phase Ib/II trial assessing the safety and best dose of trametinib (MEK inhibitor) in combination with pembrolizumab (anti-PD-1 antibody) for the treatment of patients with metastatic, recurrent, locally advanced, and unresectable NSCLC [38]. The gene discussed is MAP2K7; the disease is non-small cell lung carcinoma.