BRAF and metastatic melanoma: NCT03235245 is a phase II study evaluating the effect of combination targeted therapy (encorafenib and binimetinib) followed by combination immunotherapy (ipilimumab and nivolumab) compared with combination immunotherapy alone (ipilimumab and nivolumab) in patients with BRAF V600-mutated unresectable or metastatic melanoma [38].