Recently, CDK6 but not CDK4 was found to be a direct target of MLL-fusion proteins in infant MLL-AF4+ (MLL-ALL1-fused gene from chromosome 4 protein) ALL [87] and in MLL-AF9+ (MLL-ALL1-fused gene from chromosome 9 protein) AML [41]. This evidence concerns the gene CDK6 and acute myeloid leukemia.