Considering the above, this work aimed to determine the expression of miR-106b-5p and TRAIL in patients with gastric disease, including patients with gastric cancer, infected or not by H. pylori, We took miR-106b-5p as a focus of this study since only a few works correlated this gene to gastric cancer and the TRAIL, including the presence of H. pylori as a parameter to the analysis. This evidence concerns the gene TNFSF10 and gastric cancer.