HAVCR1 and acute kidney injury: Figure 5 shows tubular Kim-1 expression in LPS-induced AKI. Representative photographs show Kim-1+ cells in the kidney at 48 h (Figure 5A,B). There were more Kim-1+ cells in tubules from the control mice (Figure 5A). In the rTM-treatment mice, Kim-1 was not detected in the kidney (Figure 5B). Figure 5C shows that the number of Kim-1+ cells in rTM-treatment mice was significantly lower than that of the control mice at 48 h. We also investigated Kim-1 mRNA expression and found significantly lower levels of expression in the rTM-treatment mice than in the control mice (Figure 5D).