RIPK3 and cancer: A final potential issue is that the human epithelial cancer cell lines (e.g., adenocarcinoma A549 type II alveolar epithelial cells) used to examine IAV-mediated cell death, have been shown to be more resistant to IAV cell death in comparison to primary cell counterparts [33], potentially due to a lack of receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression that can trigger extrinsic apoptotic and necroptotic cell death signalling, and coordinate NLRP3 inflammasome activation [67,68,69,70,71,72,73].