Combined analysis of Cm, CRP and albumin demonstrated especially high diagnostic sensitivity of 93.3% with a specificity of 85.3% (AUC = 0.929) (Figure 2A), however, the combination of Cm, CRP, albumin and irisin achieved a reduction in the sensitivity to 80%, but the considerable specificity of 97.1% was demonstrated (AUC = 0.949) (Figure 2B) as distinguishing between cachectic and non-cachectic CHF patients. Here, FNDC5 is linked to congestive heart failure.