The authors evaluated eighty-six subjects (33 patients with myocardial infarction, 33 patients with myocardial infarction and heart failure, and 20 controls) and found negative correlations between irisin and BMI, WHR, SBP, DBP, troponin-I, CK-MB, TNF-α, TC, TGs, and LDL-C. The gene discussed is FNDC5; the disease is heart failure.