It has been shown that a single-pass transmembrane glycoprotein CD326/EpCAM was often enriched in EVs derived from cancer stem cells (CSC, aka cancer-initiating cells (CIC)) and a cleaved intracellular domain of CD326/EpCAM was able to translocate intranuclearly to then exert transcriptional control [39,40]. Here, EPCAM is linked to cancer.