MAPK8 and psoriasis: This analysis produced a list of 9 significantly altered canonical pathways (p < 0.05 or –log p-value > 1.30) including SAPK/JNK signaling, NAD biosynthesis and salvage pathway, phototransduction pathway, VDR/RXR activation, Reelin signaling in neurons, and role of IL-17A in psoriasis (Table 5).