CD274 and classic Hodgkin lymphoma: High PD-L1+CD68+/CD68+ ratio remained as an adverse prognostic factor for FFTF, DSS and OS when adjusted for cHL subtype, and also for FFTF and DSS when adjusted for stage or EBV status, whereas the association with OS remained significant only in the EBV negative cases (EBV-, HR = 7.687, (95% CI 1.067–55.362), p = 0.043; EBV+, HR = 1.860 (95% CI 0.306–11.296), p = 0.500) and was more evident in the patients with advanced than limited stage (Stage IIB-IV, HR = 3.824 (95% CI 0.935–15.636), p = 0.062; stage I-IIA, HR = 0.043 (95% CI 0.000–2.971 ×1011), p = 0.835).